长期接触“白电油”溶剂的大鼠的远端肾小管功能障碍。

Distal tubular dysfunction in rats chronically exposed to a 'white spirit' solvent.

作者信息

Viau C, Bernard A, Lauwerys R

出版信息

Toxicol Lett. 1984 Apr;21(1):49-52. doi: 10.1016/0378-4274(84)90222-4.

PMID:6719487

Abstract

Inhalation exposure of male Sprague-Dawley rats to an industrial white-spirit solvent composed of a C10-C12 mixture of branched-chain unsubstituted satured aliphatic hydrocarbons at 6500 mg/m3 for over 9 months resulted in decreased urinary concentrating ability, decreased net acid excretion following a mild ammonium chloride load and increased urinary lactate dehydrogenase (LDH) activity, whereas urinary beta-N-acetyl-D-glycosaminidase (NAG) activity remained normal. These observations suggest the existence of distal tubular alteration in the rat kidney.

摘要

将雄性斯普拉格-道利大鼠暴露于浓度为6500毫克/立方米的由支链未取代饱和脂肪烃的C10 - C12混合物组成的工业白酒精溶剂中，暴露时间超过9个月，结果导致尿浓缩能力下降、氯化铵轻度负荷后净酸排泄减少以及尿乳酸脱氢酶（LDH）活性增加，而尿β-N-乙酰-D-氨基葡萄糖苷酶（NAG）活性保持正常。这些观察结果表明大鼠肾脏远端小管存在改变。