[Effect of trimecaine, ajmaline, stenopril and chloracizine on fluctuations in K+ currents in rat liver mitochondria].

Antianginal hypotensive preparations chloracyzin and stenopryl, antiarrhythmic aimalin as well as local anesthetic and antiarrhythmic trimekaine hydrochloride were studied for their effect on the K+ inflow and outflow rate in the rat liver mitochondria during Sr2+-induced vibrations. In spite of differences in the chemical structure and pharmacological effect, all these substances are shown to uniformly suppress ion flow vibrations in mitochondria, inhibiting K+ outflow. It is found that the inhibition of the K+ outflow rate depends on the concentration of the preparations. Activity of the studied substances as to inhibition of K+ outflow from mitochondria correlates with their pharmacologic activity.