Kaverina N V, Senova Z P, Lyskovtsev V V
Kardiologiia. 1978 Apr;18(4):67-72.
The antiarrhythmic activity of some acyl derivatives of phenothiazine was studied. Ethmozine proved to be the most effective among them. It produced a marked antiarrhythmic effect both in experiments and in the clinic. The effect of ethmozine is similar to that of quinidine, but it has a wider therapeutic range and is less toxic. The drug has practically no effect or arterial pressure, myocardial conduction and myocardial contraction. These properties of ethmozine as well as its ability to prolong the refractory period and reduce myocardial excitability allow it to be recommened for the management of tachyarrhythmic a-rhythmia.
对一些吩噻嗪酰基衍生物的抗心律失常活性进行了研究。结果表明，乙吗噻嗪是其中最有效的。它在实验和临床中均产生了显著的抗心律失常作用。乙吗噻嗪的作用与奎尼丁相似，但治疗范围更广且毒性更小。该药对动脉血压、心肌传导和心肌收缩几乎没有影响。乙吗噻嗪的这些特性以及它延长不应期和降低心肌兴奋性的能力使其被推荐用于治疗快速性心律失常。
