Abdullah A S, Sheikh-Omar A R, Baggot J D, Zamri M
Vet Res Commun. 1984 Feb;8(1):55-9. doi: 10.1007/BF02214695.
One of 13 healthy dogs used in a pharmacokinetic study of imidocarb dipropionate died due to difficulty in breathing, tachycardia, weakness and profuse diarrhoea. Autopsy findings showed marked pulmonary congestion and oedema. Kidneys were grossly enlarged and markedly congested with extensive haemorrhage in the cortex and medulla. Marked tubulonephrosis was also exhibited microscopically. Liver and spleen were moderately enlarged and congested. The adverse effects of imidocarb may be due to excessive acetylcholine action.
在一项双丙酸咪唑苯脲药代动力学研究中使用的13只健康犬中，有1只死于呼吸困难、心动过速、虚弱和严重腹泻。尸检结果显示肺部明显充血和水肿。肾脏明显肿大，皮质和髓质显著充血并伴有广泛出血。显微镜下还显示出明显的肾小管肾病。肝脏和脾脏中度肿大并充血。咪唑苯脲的不良反应可能是由于乙酰胆碱作用过度所致。
