[Acute granulocytopenia caused by cimetidine].

We observed three patients, who had shown a leuco - or granulocytopenia under application of the H2 receptor-antagonist Cimetidine. Cimetidine had been given in all cases i.v. and together with other partly cytotoxic substances. After ceasing the four to seven days Cimetidine therapy all patients showed a normalization within four days.