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[脑功能丧失期间肝脏的生化及超微结构变化]

[Biochemical and ultrastructural changes of the liver during the loss of cerebral function].

作者信息

Schiffner H, Kemmer C, Kunze K D, Kopprasch S, Orlik H

出版信息

Z Exp Chir Transplant Kunstliche Organe. 1984;17(1):38-45.

PMID:6719971
Abstract

Biochemical and electron optical changes in the liver cell were recorded at the experimental brain death in dogs. The investigation results refer to a hypoxic lesion at the beginning of the brain death despite of a strong flow in the hepatic artery and the portal vein. An enlarged shunt flow is discussed to be the cause.--A distinct recovery tendency shows the morphological picture at the state of the brain death despite reducing the hepatic blood-flow and without aimed therapeutic measures. This recovery tendency appears better in the electron microscopical finding than in the behaviour of the cell metabolites.

摘要

在犬实验性脑死亡时记录了肝细胞的生化和电子光学变化。研究结果表明,尽管肝动脉和门静脉血流充足,但在脑死亡开始时仍存在缺氧性损伤。有人认为分流流量增大是其原因。——尽管肝血流量减少且未采取针对性治疗措施,但在脑死亡状态下形态学表现出明显的恢复趋势。这种恢复趋势在电子显微镜检查结果中比在细胞代谢物的表现中更为明显。

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