Janion C
Acta Biochim Pol. 1984;31(1):183-92.
A brief survey is presented on the problem of base-analogue-induced mutagenesis. The main conclusions are as follows: (i) Since some of the base analogues may induce the SOS response, the probability exists that, in these cases, some of the mutants may arise via umuC-mediated misrepair mutagenesis; (ii) At least two cellular systems may influence base-analogue-induced mutagenesis: DNA polymerases and mismatch repair systems. Whereas the first may influence the yield of mutations, the second may affect both the yield and specificity of mutations; (iii) Specificity of base-analogue-induced mutations is much more differentiated than hitherto believed. Some of the base analogues are highly specific mutagens, e.g. N4- hydroxycytidine , which induces almost exclusively AT----GC base-pair transitions, whereas the others, e.g. 2-aminopurine and 2-amino-N6- methoxyadenine , may induce both transitions and transversions.
本文简要综述了碱基类似物诱导诱变的问题。主要结论如下：(i) 由于某些碱基类似物可能诱导SOS反应，因此在这些情况下，存在一些突变体可能通过umuC介导的错配修复诱变产生的可能性；(ii) 至少有两个细胞系统可能影响碱基类似物诱导的诱变：DNA聚合酶和错配修复系统。前者可能影响突变率，而后者可能影响突变率和突变特异性；(iii) 碱基类似物诱导突变的特异性比迄今认为的要复杂得多。一些碱基类似物是高度特异性的诱变剂，例如N4-羟基胞苷，它几乎只诱导AT→GC碱基对转换，而其他一些，例如2-氨基嘌呤和2-氨基-N6-甲氧基腺嘌呤，则可能诱导转换和颠换。
