Vilhardt H, Bie P
Acta Endocrinol (Copenh). 1984 Apr;105(4):474-6. doi: 10.1530/acta.0.1050474.
Urine volume and osmolality were measured in volunteers hydrated with drinking water (2% of body weight). During maintained water diuresis DDAVP (1-deamino-8-D-arginine vasopressin) dissolved in water was administered per os. Within 15-30 min a dose-dependent antidiuretic response occurred with a concomitant increase in urine osmolality. Administration of DDAVP through a duodenal tube caused similar antidiuretic effects indicating that the intact peptide can be absorbed from the intestinal mucosa.
