Reeves W C, Brenes M M, de Britton R C, Valdes P F, Joplin C F
Am J Epidemiol. 1984 May;119(5):714-24. doi: 10.1093/oxfordjournals.aje.a113792.
Cervical cancer is more common in Latin America than elsewhere in the world. Previous work indicated that Panama also had a high incidence of cervical cancer and that the disease clustered in rural Herrera Province; to document this and collect detailed information on risk factors, the authors established a population-based Cervical Cancer Registry in Panama. Cervical cancer cases diagnosed between 1974 and 1979 were identified by visiting every major hospital in the country. The registry abstracted epidemiologic, clinical, and other information from patients' hospital charts. It recorded an age-adjusted invasive cervical cancer incidence of 28.4/100,000 between 1974 and 1979; rural Herrera Province supported the highest rate (79.1/100,000), while urban Panama Province had a low rate (24.6/100,000); in situ disease followed a similar pattern (48.7/100,000 in Herrera Province and 17.6/100,000 in Panama Province). Women born in Herrera Province retained high cervical cancer rates irrespective of residence at diagnosis (64.7/100,000), while women from Panama Province had low rates (12.4/100,000) which were comparable to those seen in US whites. In addition to having high cancer rates, women from Herrera Province developed invasive disease at an unusually young age; women between 35 and 39 years of age had an incidence of 151/100,000.
宫颈癌在拉丁美洲比世界其他地区更为常见。先前的研究表明，巴拿马的宫颈癌发病率也很高，且该疾病在农村地区的埃雷拉省呈聚集性分布；为了记录这一情况并收集有关风险因素的详细信息，作者在巴拿马建立了一个基于人群的宫颈癌登记处。通过走访该国的每一家主要医院，确定了1974年至1979年间诊断出的宫颈癌病例。该登记处从患者的医院病历中提取了流行病学、临床及其他信息。记录显示，1974年至1979年间，年龄调整后的浸润性宫颈癌发病率为28.4/10万；农村的埃雷拉省发病率最高（79.1/10万），而巴拿马省省会城市的发病率较低（24.6/10万）；原位癌的情况也类似（埃雷拉省为48.7/10万，巴拿马省为17.6/10万）。出生在埃雷拉省的女性，无论诊断时居住在哪里，宫颈癌发病率都很高（64.7/10万），而来自巴拿马省的女性发病率较低（12.4/10万），与美国白人的发病率相当。除了癌症发病率高之外，埃雷拉省的女性患浸润性疾病的年龄异常小；35至39岁的女性发病率为151/10万。
