Pollak P T, Sami M
Am J Med. 1984 May;76(5):935-9. doi: 10.1016/0002-9343(84)91014-3.
Amiodarone is a new and powerful antiarrhythmic agent currently under investigation in North America. In the past two years, there have been increasing reports of serious side effects associated with its use, including 14 cases of pneumonitis or pulmonary fibrosis. This report describes a case of acute necrotizing pneumonitis, a complication that has not been observed previously with amiodarone therapy. Amiodarone also appeared to alter carbohydrate metabolism in this patient. Metabolic changes induced by this drug may be mediated by superoxide radicals. A high index of suspicion for pulmonary complications should be maintained in patients taking amiodarone, and nonspecific respiratory complaints should be investigated carefully.
胺碘酮是一种新型强效抗心律失常药物，目前正在北美进行研究。在过去两年中，关于其使用所引发的严重副作用的报道日益增多，其中包括14例肺炎或肺纤维化病例。本报告描述了一例急性坏死性肺炎病例，这是一种此前在胺碘酮治疗中未曾观察到的并发症。胺碘酮似乎还改变了该患者的碳水化合物代谢。这种药物引起的代谢变化可能由超氧自由基介导。对于服用胺碘酮的患者，应高度怀疑其肺部并发症，对于非特异性呼吸道症状应仔细进行调查。
