Randolph D I, Schmeisser E T, Beatrice E S
Am J Optom Physiol Opt. 1984 Mar;61(3):190-5. doi: 10.1097/00006324-198403000-00007.
A series of experiments was performed to determine the parameters necessary to produce immediate measurable changes in the visual system of nonhuman primates after exposure of the fovea to laser radiation. The parameters investigated were stimulus spatial frequency (1.6 and 2.8 c/deg), size of the visual field stimulated (30 and 3.6 degrees), retinal diameter of the laser exposure (50 and 500 micron), and total intraocular energy. Steady-state visual evoked potentials (VEP's) were recorded from cynomolgus monkeys in response to an oscillating grating. Single 20 ns Q-switched ruby laser pulses (694.3 nm) were directed into the fovea of the experimental eye during the pattern stimulation. No immediate effects on the VEP were noted. Strong delayed effects occurred 45 to 120 s postexposure and were characterized by large phase shifts in the response signal as referenced to the stimulus, magnitude decreases, variance increases, and a loss of waveform correlation with pre-exposure baseline signals. These effects persisted for approximately 30 s before the VEP again became normally re-entrained.
进行了一系列实验，以确定在中央凹暴露于激光辐射后，在非人灵长类动物视觉系统中产生即时可测量变化所需的参数。所研究的参数包括刺激空间频率（1.6和2.8周/度）、受刺激视野的大小（30和3.6度）、激光照射的视网膜直径（50和500微米）以及眼内总能量。在对猕猴进行图案刺激时，记录其对振荡光栅的稳态视觉诱发电位（VEP）。在图案刺激期间，将单个20纳秒调Q红宝石激光脉冲（694.3纳米）对准实验眼的中央凹。未观察到对VEP的即时影响。暴露后45至120秒出现强烈的延迟效应，其特征是与刺激相关的响应信号出现大的相位偏移、幅度减小、方差增加以及波形与暴露前基线信号的相关性丧失。这些效应持续约30秒，之后VEP再次恢复正常同步。
