Ishikawa N, Kallman C H, Sagawa K
Am J Physiol. 1984 May;246(5 Pt 2):H696-701. doi: 10.1152/ajpheart.1984.246.5.H696.
To determine the effects of different anesthesias on the performance of the arterial baro-reflex, the open-loop characteristic of the carotid sinus reflex was analyzed in 24 rabbits under anesthesia with pentobarbital (30 mg/kg), urethan (800 mg/kg), alpha-chloralose (80 mg/kg), or a mixture of alpha-chloralose (40 mg/kg) and urethan (0.4 g/kg). For each rabbit and anesthesia, mean systemic arterial pressure and heart rate were measured as carotid sinus pressure was changed in 10-mmHg steps between 40 and 150 mmHg. This set of measurements was repeated four times at 1-h intervals. A logistic function curve was fitted to the carotid sinus pressure-arterial pressure relationship. The parameters of this curve were then analyzed to delineate the specific effects of the anesthesias on the relationship. The main finding was that the response range and the slope parameters under alpha-chloralose anesthesia were significantly smaller than those obtained under the other anesthesias. Propylene glycol, used as the solvent for chloralose, did not affect the reflex control of arterial pressure or heart rate. The reflex under chloralose-urethan anesthesia showed characteristics similar to those under urethan anesthesia. We conclude that although alpha-chloralose has traditionally been used in the dog to obtain strong reflex responses, it weakens the reflex control of arterial pressure in the rabbit.
为了确定不同麻醉方式对动脉压力反射性能的影响，在24只分别用戊巴比妥（30mg/kg）、乌拉坦（800mg/kg）、α-氯醛糖（80mg/kg）或α-氯醛糖（40mg/kg）与乌拉坦（0.4g/kg）混合物麻醉的兔子身上，分析了颈动脉窦反射的开环特性。对于每只兔子和每种麻醉方式，当颈动脉窦压力在40至150mmHg之间以10mmHg步长变化时，测量平均体循环动脉压和心率。这组测量在1小时间隔内重复4次。将逻辑函数曲线拟合到颈动脉窦压力与动脉压的关系上。然后分析该曲线的参数，以描述麻醉对该关系的具体影响。主要发现是，α-氯醛糖麻醉下的反应范围和斜率参数明显小于其他麻醉方式下获得的参数。用作氯醛糖溶剂的丙二醇不影响动脉压或心率的反射控制。氯醛糖-乌拉坦麻醉下的反射表现出与乌拉坦麻醉下相似的特征。我们得出结论，尽管传统上在狗身上使用α-氯醛糖以获得强烈的反射反应，但它会削弱兔子对动脉压的反射控制。
