Mihara M
Arch Dermatol Res. 1984;276(2):115-22. doi: 10.1007/BF00511068.
To elucidate the regeneration of cutaneous nerves in human skin, biopsy specimens were taken from the regenerated skin of extremities of five adult men with third degree burns that had occurred about 3 weeks previously. Numerous subepidermal nerves could be detected in the newly formed granulation tissue, independent of the blood vessels. These nerves were axon-Schwann's cell complexes. Some axons were packed with small clear vesicles 40-60 nm in diameter or large dense-cored vesicles 70-100 nm in diameter and large dense bodies. Schwann's cell components showed a relatively abundant cytoplasm and many microfilaments. Intraepidermal nerves were frequently encountered in the interspace between the basal lamina and the cytomembrane of basal keratinocytes in most cases or in the intercellular spaces between basal keratinocytes; however, they were never seen in and beyond spinous layers. They were seen as axon-Schwann's cell complexes or naked axons. In one case a Schwann's cell containing axons migrated into the epidermis. These findings suggest that cutaneous nerves may show hyperregeneration in very early stages of wound healing.
为阐明人类皮肤中皮神经的再生情况，从5名成年男性大约3周前发生的三度烧伤肢体再生皮肤处获取活检标本。在新形成的肉芽组织中可检测到大量表皮下神经，这些神经与血管无关。这些神经是轴突 - 施万细胞复合体。一些轴突内充满直径40 - 60nm的小清亮小泡或直径70 - 100nm的大致密核心小泡以及大致密体。施万细胞成分显示细胞质相对丰富且有许多微丝。在大多数情况下，表皮内神经常见于基底层与基底角质形成细胞细胞膜之间的间隙或基底角质形成细胞之间的细胞间隙中；然而，在棘层及以上从未见过。它们表现为轴突 - 施万细胞复合体或裸露的轴突。在1例中，1个含有轴突的施万细胞迁移至表皮。这些发现提示在伤口愈合的极早期皮神经可能呈现过度再生。
