Alousi A A, Iwan T, Edelson J, Biddlecome C
Arch Int Pharmacodyn Ther. 1984 Jan;267(1):59-66.
The relationship between the hemodynamic effects of milrinone and its plasma concentration was studied in the anesthetized instrumented dog. Milrinone was administered intravenously either as a single bolus of 10, 30 or 100 micrograms/kg or infused at a rate of 10 micrograms/kg/min. The changes in drug plasma concentration and cardiovascular parameters were determined simultaneously during the course of drug action. The intravenous bolus injections of milrinone caused dose-dependent increases in its maximum plasma concentration that resulted in concomitant increases in both cardiac contractile force and heart rate with simultaneous decreases in systolic and diastolic blood pressure. The intravenous infusion of milrinone caused parallel increases in both drug plasma concentration and cardiac contractile force; following termination of the milrinone infusion, there was a gradual decline in both its plasma concentration and in its inotropic activity, with a similar time course for these two parameters. A positive correlation (r = 0.78; p less than 0.008) was obtained between milrinone plasma concentration and its inotropic effect.
在麻醉的有创监测犬中研究了米力农的血流动力学效应与其血浆浓度之间的关系。米力农以10、30或100微克/千克的单次静脉推注给药，或以10微克/千克/分钟的速率静脉输注。在药物作用过程中同时测定药物血浆浓度和心血管参数的变化。静脉推注米力农导致其最大血浆浓度呈剂量依赖性增加，这导致心脏收缩力和心率同时增加，同时收缩压和舒张压降低。静脉输注米力农导致药物血浆浓度和心脏收缩力平行增加；米力农输注终止后，其血浆浓度和变力活性均逐渐下降，这两个参数的时间进程相似。米力农血浆浓度与其变力效应之间呈正相关（r = 0.78；p < 0.008）。
