Schmidt-Nowara W W, Marder E J, Feil P A
Arch Neurol. 1984 May;41(5):567-8. doi: 10.1001/archneur.1984.04050170117030.
Paroxysmal dyspnea and stridor in a patient with myasthenia were shown to be due to weakness of vocal cord abductors that improved with anticholinesterase therapy. Despite adequate inspiratory force, breathing was severely impaired by increased inspiratory resistance. The inspiratory flow-volume loop was useful in documenting the laryngeal obstruction and monitoring the effect of therapy. Reinterpretation of previous studies suggests that upper airway obstruction may often contribute to respiratory failure in patients with myasthenia.
一名重症肌无力患者出现的阵发性呼吸困难和喘鸣被证明是由于声带外展肌无力所致，抗胆碱酯酶治疗后症状有所改善。尽管吸气力量充足，但吸气阻力增加严重损害了呼吸功能。吸气流量-容积环有助于记录喉部梗阻情况并监测治疗效果。对既往研究的重新解读表明，上气道梗阻可能常常导致重症肌无力患者发生呼吸衰竭。
