喂食致癌性甲基缺乏饮食的大鼠肝脏细胞核DNA的低甲基化
Hypomethylation of hepatic nuclear DNA in rats fed with a carcinogenic methyl-deficient diet.
作者信息
Wilson M J, Shivapurkar N, Poirier L A
出版信息
Biochem J. 1984 Mar 15;218(3):987-90. doi: 10.1042/bj2180987.
Abstract
A progressive decrease was observed in the 5-methyldeoxycytidine content of hepatic DNA in male F344 rats fed with a hepatocarcinogenic methyl-deficient diet. The same dietary regimen resulted in altered hepatic contents of S-adenosylmethionine, the methyl-donating species, and S-adenosylhomocysteine, an inhibitor of DNA methylase. The data indicate that this carcinogenic dietary manipulation is sufficient to alter a possible regulatory process, DNA methylation.
摘要
在用致肝癌的甲基缺乏饮食喂养的雄性F344大鼠中，观察到肝脏DNA中5-甲基脱氧胞苷含量逐渐降低。相同的饮食方案导致肝脏中甲基供体物质S-腺苷甲硫氨酸和DNA甲基化酶抑制剂S-腺苷高半胱氨酸的含量发生改变。数据表明，这种致癌性饮食操作足以改变一种可能的调控过程，即DNA甲基化。
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