Pond C M, Mattacks C A, Sadler D
Br J Nutr. 1984 May;51(3):425-33. doi: 10.1079/bjn19840048.
Two intermuscular adipose depots, the popliteal mass (POP) and the fat under the gluteus superficialis muscle ( GLS ) were studied in guinea-pigs maintained under three different regimes of diet and exercise. Eleven different sites in POP and four sites in GLS were defined using associated muscle and fascia as 'landmarks'. Samples of twenty to twenty-five adipocytes from each site were removed and their mean volume measured; a consistent pattern of distribution of larger and smaller adipocytes within POP and GLS was found in all animals. The correlation between the volume of adipocytes from sites between the same pairs of muscles was substantially greater than the correlation between the volume of adipocytes from comparable sites between different muscles, whether the sites were within the same fat mass (POP) or in different fat masses (POP and GLS ). The volume of adipocytes from the edge of the fat mass correlated more closely with those from the edge of the same or a synergistic muscle than with the volume of cells from the centre sites or edge sites from an interface with another muscle. These effects were most pronounced in exercised animals and weak or insignificant in sedentary ad lib.-fed animals. The volume of adipocytes from edge sites correlated with the gross weight of the adjacent muscles in exercised animals only. It is concluded that muscle activity has a local effect on the volume of adjacent adipocytes. It is suggested that the mechanism involved is mechanical rather than biochemical.
在三种不同饮食和运动方案下饲养的豚鼠中，研究了两个肌间脂肪库，即腘窝脂肪块（POP）和臀浅肌下脂肪（GLS）。利用相关肌肉和筋膜作为“地标”，确定了POP中的11个不同部位和GLS中的4个部位。从每个部位取出20至25个脂肪细胞样本并测量其平均体积；在所有动物中，均发现POP和GLS内大小脂肪细胞分布的一致模式。同一对肌肉之间部位的脂肪细胞体积相关性显著大于不同肌肉之间可比部位的脂肪细胞体积相关性，无论这些部位是在同一脂肪块（POP）内还是在不同脂肪块（POP和GLS）中。脂肪块边缘的脂肪细胞体积与来自相同或协同肌肉边缘的脂肪细胞体积相关性，比与来自中心部位或与另一肌肉界面边缘部位的细胞体积相关性更紧密。这些效应在运动的动物中最为明显，而在久坐自由采食的动物中则较弱或不显著。仅在运动的动物中，边缘部位的脂肪细胞体积与相邻肌肉的总重量相关。结论是肌肉活动对相邻脂肪细胞的体积有局部影响。有人提出所涉及的机制是机械性的而非生化性的。
