Potier M, Morin P R, Melançon S B, Dallaire L
Biol Neonate. 1984;45(5):257-60. doi: 10.1159/000242014.
Comparison of relative disaccharidase activities in jejunal mucosa, amniotic fluid, and meconium samples taken from the ileum, proximal and distal colon of 5 human fetuses, indicates that trehalase and lactase are more sensitive to the denaturation conditions existing in the fetal intestinal lumen than maltase, sucrase, palatinase and turanase . Relative activities of sensitive disaccharidases (trehalase and lactase) were also low in the amniotic fluid of these fetuses as compared to the jejunal mucosa. These results suggest that the in vivo stability of disaccharidases, exposed to proteolytic digestion and other denaturing conditions in the fetal intestinal lumen, governs the relative activities of these enzymes released into the amniotic fluid.
对取自5例人类胎儿回肠、近端结肠和远端结肠的空肠黏膜、羊水及胎粪样本中的相对双糖酶活性进行比较，结果表明，海藻糖酶和乳糖酶比麦芽糖酶、蔗糖酶、帕拉金酶和松二糖酶对胎儿肠腔内存在的变性条件更敏感。与空肠黏膜相比，这些胎儿羊水中敏感双糖酶（海藻糖酶和乳糖酶）的相对活性也较低。这些结果表明，在胎儿肠腔内暴露于蛋白水解消化和其他变性条件下的双糖酶的体内稳定性，决定了释放到羊水中的这些酶的相对活性。
