Van'ko L V, Bakuradze N N, Sukhikh G T
Biull Eksp Biol Med. 1984 Apr;97(4):440-3.
The authors studied the activity of natural killers in young and old mice and effects on this activity of interferon and its inducer (synthetic polynucleotide poly-I:C). The activity of natural killers as indicated by the 51Cr-release microtest and the content of the cells that recognize and lyse the target cells, determined in isolated conjugates in agarose were appreciably lower in old mice than in young ones. Administration of poly-I:C or interferon to the animals (or interferon treatment of splenocytes in vitro) led to an increase in the activity of natural killers in young mice, with no significant effect on old animals' cells.
作者研究了年轻和老年小鼠中自然杀伤细胞的活性，以及干扰素及其诱导剂（合成多核苷酸聚肌胞苷酸）对该活性的影响。通过51Cr释放微量试验所示的自然杀伤细胞活性，以及在琼脂糖中分离的结合物中测定的识别并裂解靶细胞的细胞含量，老年小鼠明显低于年轻小鼠。给动物注射聚肌胞苷酸或干扰素（或体外对脾细胞进行干扰素处理）可使年轻小鼠的自然杀伤细胞活性增加，而对老年动物的细胞无显著影响。
