Weinrich M, Wise S P, Mauritz K H
Brain. 1984 Jun;107 ( Pt 2):385-414. doi: 10.1093/brain/107.2.385.
The frontal agranular cortex consists of at least three major subdivisions: the precentral motor cortex, the supplementary motor cortex, and the premotor cortex. Of these, the premotor cortex is by far the least intensively studied by neurophysiological methods in spite of recent evidence that it is important in higher order aspects of the cerebral control of movement ( Moll and Kuypers , 1977; Roland et al., 1980b ; Halsband and Passingham , 1982). We have accordingly studied neuronal activity in the premotor cortex of Rhesus macaques operantly conditioned to perform a visually guided motor task. We have concluded that many premotor cortex neurons appear to reflect motor set. Further, these and other premotor cortex neurons show activity patterns during and before the execution of an abstractly guided movement that are strikingly similar to what has been observed in association with movements made directly to visuospatial targets. Finally, a functional relationship of some premotor cortex unit activity to the execution of voluntary movement is supported by its close temporal correlation with the onset of movement, a significant correlation with the acceleration of the limb in some cases, and a uniform specificity for movement execution rather than the visuospatial cues that guide the movement.
中央前运动皮质、辅助运动皮质和运动前皮质。其中，尽管最近有证据表明运动前皮质在大脑对运动的高级控制方面很重要（莫尔和库佩斯，1977年；罗兰等人，1980年b；哈尔斯班德和帕辛厄姆，1982年），但到目前为止，神经生理学方法对其研究最少。因此，我们研究了恒河猴运动前皮质中的神经元活动，这些恒河猴经过操作性条件训练以执行视觉引导的运动任务。我们得出的结论是，许多运动前皮质神经元似乎反映了运动准备状态。此外，这些以及其他运动前皮质神经元在执行抽象引导运动期间和之前的活动模式，与在直接向视觉空间目标做出的运动中观察到的模式惊人地相似。最后，运动前皮质一些单位活动与自主运动执行之间的功能关系，得到了其与运动开始的紧密时间相关性、在某些情况下与肢体加速度的显著相关性以及对运动执行而非引导运动的视觉空间线索的一致特异性的支持。
