Burne R A, Woodward D J
Brain Res Bull. 1984 Mar;12(3):267-74. doi: 10.1016/0361-9230(84)90054-6.
Regions of the midbrain in the rat were stimulated electrically with bipolar electrodes to identify responsive, single neurons in the parafloccular lobule of the cerebellum. Eighty four percent (44/52) of the cells recorded in the paraflocculus showed evidence of a modulation in simple spike discharge activity (mossy fiber activations) following stimulation with a bipolar electrode whose tip was placed in the ventral layers of the contralateral superior colliculus. Mossy fiber (MF) evoked responses were indicated by the presence of an excitation followed by an inhibition of simple spike frequency at latencies of 5-16 msec and by the demonstration of responsiveness to stimulus frequencies up to 50 Hz. Ten percent (4/41) of identified Purkinje cells in the paraflocculus demonstrated activation of complex spike potentials following stimulation of regions in the ventral superior colliculus. Experiments involving stimulation of the midbrain and visual cortices indicated that 70% of the parafloccular neurons are responsive to inputs from both the cortex and deep regions of the colliculus. Electrophysiologic evidence also is presented that demonstrates the existence of a midbrain projection to midvermal lobules VI and VII of the cerebellum.
用双极电极对大鼠中脑区域进行电刺激，以识别小脑旁绒球小叶中具有反应性的单个神经元。在用尖端置于对侧上丘腹侧层的双极电极刺激后，在旁绒球记录的细胞中有84%（44/52）显示出简单锋电位放电活动（苔藓纤维激活）受到调制的证据。苔藓纤维（MF）诱发的反应表现为在5 - 16毫秒潜伏期出现简单锋电位频率先兴奋后抑制，并且对高达50赫兹的刺激频率有反应。在旁绒球中，10%（4/41）已识别的浦肯野细胞在刺激上丘腹侧区域后表现出复合锋电位的激活。涉及刺激中脑和视觉皮层的实验表明，70%的旁绒球神经元对来自皮层和上丘深部区域的输入有反应。还提供了电生理证据，证明存在从中脑到小脑蚓部VI和VII小叶的投射。
