Burne R A, Woodward D J
Exp Brain Res. 1983;49(1):55-67. doi: 10.1007/BF00235541.
The visual cortex of the rat was electrically stimulated with monopolar tungsten electrodes to determine the response properties of single neurons in the parafloccular lobule of the cerebellum. Following stimulation of the contralateral visual cortex, mossy fiber (MF)-evoked responses were indicated in 80 of 91 cells (88%) by activation of single or double spike potentials at latencies of 6-16 ms followed by an inhibition in simple spike frequency. MF activations were further identified by the demonstration of graded responses with increasing stimulus intensity and by following stimulus frequencies up to 20 Hz. Fifteen percent (9/61) of identified Purkinje cells in the parafloccular lobule demonstrated activation by climbing fiber excitations, as identified by the characteristic all-or-none burst response, which were evoked at variable latencies between 15-31 ms and 68-115 ms. Experiments involving stimulation of the superior colliculus and lesioning of the cerebral peduncle suggest that the visual cortical projection to the paraflocculus is mediated by the cortico-ponto-parafloccular pathway rather than relayed through midbrain nuclei. The electrophysiologic evidence suggests that the paraflocculus is a major receiving lobule of the cerebellum for inputs from the visual cortices.
用单极钨电极电刺激大鼠的视觉皮层，以确定小脑旁绒球小叶中单个神经元的反应特性。在刺激对侧视觉皮层后，91个细胞中的80个（88%）出现了苔藓纤维（MF）诱发反应，表现为在6 - 16毫秒潜伏期激活单个或双个峰电位，随后简单峰频率受到抑制。通过证明随着刺激强度增加的分级反应以及跟踪高达20赫兹的刺激频率，进一步确定了MF激活。在旁绒球小叶中，15%（9/61）已鉴定的浦肯野细胞表现出由攀缘纤维兴奋激活，其特征为全或无爆发反应，在15 - 31毫秒和68 - 115毫秒之间的可变潜伏期诱发。涉及刺激上丘和损伤脑桥脚的实验表明，视觉皮层到旁绒球的投射是由皮质 - 脑桥 - 旁绒球通路介导的，而不是通过中脑核团中继。电生理证据表明，旁绒球是小脑接收来自视觉皮层输入的主要小叶。
