Warneke L B
Can J Psychiatry. 1984 Mar;29(2):135-41. doi: 10.1177/070674378402900211.
Obsessional disorder has always remained a difficult illness for psychiatrists to treat with response to therapy, both psychotherapy and chemotherapy, being low. A review of the traditional approaches to the treatment of obsessional disorder is done, including a brief review of the literature on intravenous chlorimipramine. Five case histories of patients with previously non-responsive obsessional disorder are summarized. All five cases were treated in hospital with a series of infusions of intravenous chlorimipramine. The drug and route of administration was extremely well tolerated with rapid and dramatic relief of obsessional symptoms as well as improvement of mood in all cases. The theoretical action of chlorimipramine is discussed as well as possible reasons why the intravenous route appears to be superior to the oral form.
强迫障碍一直是精神科医生难以治疗的疾病，无论是心理治疗还是药物治疗，其疗效都很低。本文回顾了治疗强迫障碍的传统方法，包括对静脉注射氯米帕明文献的简要回顾。总结了5例既往对治疗无反应的强迫障碍患者的病例史。所有5例患者均在医院接受了一系列静脉注射氯米帕明的治疗。该药物及其给药途径耐受性极佳，所有病例的强迫症状均迅速得到显著缓解，情绪也有所改善。本文讨论了氯米帕明的理论作用，以及静脉给药途径似乎优于口服给药途径的可能原因。
