DiPette D, Gavras I, North W, DiPette P, Gavras H
Clin Exp Hypertens A. 1984;6(4):851-61. doi: 10.3109/10641968409044042.
We have investigated the interaction of plasma vasopressin and plasma catecholamines in quadriplegic patients (with severed sympathetic tracts) and compared them to others with intact sympathetic system following I.V. administration of a hyperosmolar radiocontrast agent during a routine diagnostic pyelography. Baseline systolic and diastolic pressure as well as plasma norepinephrine were significantly lower in the quadriplegic subjects. At 5 minutes after administration of the hyperosmolar solution, systolic and diastolic pressure as well as plasma vasopressin rose in the quadriplegic subjects but not in normal subjects despite a significant and equal rise in serum osmolality occurring in both groups. These results demonstrate that an interaction between the two systems exists in humans: an intact sympathetic nervous system attenuates the vasopressin response to hyperosmolar stimuli and in its absence vasopressin may function as a pressor agent.
我们研究了四肢瘫痪患者（交感神经束切断）血浆血管加压素与血浆儿茶酚胺之间的相互作用，并将其与交感神经系统完整的其他患者进行比较，这些患者在常规诊断性肾盂造影期间静脉注射了高渗性放射性造影剂。四肢瘫痪受试者的基线收缩压和舒张压以及血浆去甲肾上腺素显著较低。给予高渗溶液5分钟后，四肢瘫痪受试者的收缩压和舒张压以及血浆血管加压素升高，而正常受试者则未升高，尽管两组的血清渗透压均显著且同等升高。这些结果表明，人类的这两个系统之间存在相互作用：完整的交感神经系统减弱了血管加压素对高渗刺激的反应，在其缺失的情况下，血管加压素可能起升压剂的作用。
