Black F W, Bernard B A
Cortex. 1984 Mar;20(1):111-20. doi: 10.1016/s0010-9452(84)80028-3.
Patients with penetrating missile wounds confined to one of the four brain quadrants were evaluated to determine the incidence and severity of constructional apraxia. The visual constructive tasks used were the WAIS Block Designs subtest and the Bender Gestalt (reproduction) Test. Estimates of lesion size were used to investigate the effect of this factor on constructional ability. Patients with right posterior lesion tended to perform least adequately in general, although significant differences were obtained only for the Bender Gestalt Test. The effect for lesion laterality was greater than that for caudality , although neither analysis reached statistical significance. Lesion size made a relatively minor contribution to the visual constructional deficits in this sample. Only in the left posterior sample did lesion size correlate significantly with measures of constructional impairment. The lack of consistent findings may have been due to the restricted lesion size in these patients and to the absence of significant cognitive deficits in most subjects. The results support either a regional interpretation of the mass action theory or the possible role of deficient verbal mediation in the constructional performance of patients with left hemisphere lesions. This study emphasizes the importance in neurobehavioral research of controlling potentially confounding variables (e.g., lesion size and type of associated cognitive deficits) when studying any specific aspect of neuropsychological functioning.
对局限于四个脑区之一的穿透性导弹伤患者进行评估，以确定结构性失用症的发生率和严重程度。所使用的视觉构建任务是韦氏成人智力量表（WAIS）中的积木图案分测验和本德尔格式塔（复制）测验。利用损伤大小的估计值来研究该因素对构建能力的影响。一般来说，右侧后部损伤的患者表现往往最差，不过仅在本德尔格式塔测验中获得了显著差异。损伤部位的影响大于损伤尾侧的影响，尽管两项分析均未达到统计学显著性。在这个样本中，损伤大小对视觉构建缺陷的影响相对较小。仅在左侧后部样本中，损伤大小与构建损伤的测量指标显著相关。缺乏一致的研究结果可能是由于这些患者的损伤大小受限，以及大多数受试者没有明显的认知缺陷。这些结果支持对质量作用理论的区域解释，或者支持言语中介不足在左半球损伤患者构建表现中可能发挥的作用。本研究强调在神经行为研究中，当研究神经心理功能的任何特定方面时，控制潜在混杂变量（如损伤大小和相关认知缺陷的类型）的重要性。
