Appel P L, Shoemaker W C
Crit Care Med. 1984 Jun;12(6):528-9.
The hemodynamic and oxygen transport effects of prostaglandin E1 (PGE1, Prostin -VR), in increasing doses from 1 to 30 ng/kg X min were evaluated in 5 severely ill surgical patients with adult respiratory distress syndrome (ARDS). This agent produced marked reductions in pulmonary arterial and venous pressures, and increases in cardiac output and oxygen transport. Improvement in PaO2 occurred several hours after these effects. The data indicate that this agent may be a useful adjunctive therapy for ARDS.
在5例患有成人呼吸窘迫综合征（ARDS）的重症外科患者中，评估了前列腺素E1（PGE1，普洛斯坦-VR）以1至30 ng/kg×分钟递增剂量时的血流动力学和氧输送效应。该药物使肺动脉压和静脉压显著降低，并使心输出量和氧输送增加。这些效应出现数小时后，动脉血氧分压（PaO2）有所改善。数据表明，该药物可能是ARDS的一种有用的辅助治疗方法。
