van den Broek M D, Bradshaw C M, Szabadi E
Eur J Clin Pharmacol. 1984;26(2):209-13. doi: 10.1007/BF00630287.
The responsiveness of eccrine sweat glands to local intradermal injections of carbachol was studied in six male healthy volunteers using a plastic paint impression method. A psychological "stressor" (performance of a mental arithmetic task) resulted in an increase in the sizes of the responses evoked by carbachol, this being reflected in a higher value of Emax obtained under the "stress" than under the "non-stress" condition. A rise in ambient temperature from 20 degrees C to 35 degrees C resulted in qualitatively similar effects on the dose-response curve. These results are discussed in the context of recent observations on the pharmacological responsiveness of sweat glands in patients suffering from anxiety neurosis.
采用塑料涂料印记法，对6名男性健康志愿者的外分泌汗腺对皮内局部注射卡巴胆碱的反应性进行了研究。心理“应激源”（进行心算任务）导致卡巴胆碱诱发的反应大小增加，这体现在“应激”条件下获得的Emax值高于“非应激”条件下的值。环境温度从20摄氏度升至35摄氏度对剂量反应曲线产生了定性相似的影响。结合近期对焦虑神经症患者汗腺药理反应性的观察结果对这些结果进行了讨论。
