Bonilla E
Exp Neurol. 1984 Jun;84(3):696-700. doi: 10.1016/0014-4886(84)90216-4.
Two groups of adult male Sprague-Dawley rats were treated with manganese added to the drinking water in concentrations of 0.1 and 5.0 mg Mn2+/ml. Age-matched controls received distilled demineralized water. Spontaneous motor activity, measured in 60-min weekly sessions during 8 months, showed a significant increase during the 1st month. Further exposure did not affect the motor activity to 6 months. But, on months 7 and 8 a significant reduction was observed compared with controls. Both hyper- and hypoactivity were not dose-dependent as the results obtained in both groups of manganese-exposed rats were similar. These findings should make health authorities aware of the potential involvement of low doses of manganese in the development of early behavioral problems long before the irreversible neurologic damage is established.
将两组成年雄性斯普拉格-道利大鼠的饮用水中添加浓度为0.1和5.0毫克锰离子/毫升的锰。年龄匹配的对照组饮用蒸馏去离子水。在8个月内每周进行60分钟的自发运动活动测量，结果显示在第1个月运动活动显著增加。进一步暴露至6个月对运动活动没有影响。但是，在第7个月和第8个月时，与对照组相比运动活动显著降低。高活性和低活性均不依赖剂量，因为两组锰暴露大鼠的结果相似。这些发现应使卫生当局意识到，在不可逆转的神经损伤形成之前很久，低剂量锰可能参与早期行为问题的发展。
