Nooter K, Meershoek B, Spaans W, Sonneveld P, Oostrum R, Deurloo J
Experientia. 1984 Jun 15;40(6):559-61. doi: 10.1007/BF01982329.
After a single oral dose of cyclosporin A (82 mg/kg) in rats, tissue (kidneys liver and brain) and blood levels reached maximum values (approximately 80 micrograms/g and 3.5 micrograms/ml) between 3 and 7 h after drug administration. Drug elimination continued for at least 5 days. The 24-h urine and bile elimination was 2% for each.
大鼠单次口服环孢素A（82毫克/千克）后，给药后3至7小时，组织（肾脏、肝脏和大脑）及血液中的药物水平达到最大值（分别约为80微克/克和3.5微克/毫升）。药物消除持续至少5天。24小时尿液和胆汁的消除率均为2%。
