Hornnes P J, Kühl C
Diabete Metab. 1984 Jan;10(1):1-6.
The possible correlations between the increase in cortisol levels and the decrease in glucose tolerance and changes in insulin and glucagon secretion in normal pregnancy were studied in 17 normal pregnant women. Total and free plasma cortisol concentrations and urinary cortisol excretion rate were measured monthly from week 12 and the results were related to the changes in glucose tolerance in early, mid, and late pregnancy and finally compared to postpartum findings. In early pregnancy, total and free plasma cortisol concentrations and the urinary cortisol excretion rate were already higher than postpartum and the levels increased further throughout gestation, reaching maximum levels at term. Glucose tolerance deteriorated during pregnancy. When the increases during pregnancy in total and free plasma cortisol concentrations and urinary cortisol excretion rates on the one hand and the deterioration of glucose tolerance on the other hand were related, significant positive correlations were obtained (r-values between 0.55 and 0.63, p less than 0.05). No correlation was found between the increase in cortisol levels or excretion rates and the changes in the insulin and glucagon responses to glucose in pregnancy. It is concluded that the elevation of cortisol levels in pregnancy might possibly be associated with the diabetogenicity of pregnancy.
对17名正常孕妇进行研究，以探讨正常妊娠期间皮质醇水平升高与糖耐量降低以及胰岛素和胰高血糖素分泌变化之间的可能关联。从孕12周开始每月测量血浆总皮质醇和游离皮质醇浓度以及尿皮质醇排泄率，结果与孕早、中、晚期糖耐量变化相关，并最终与产后结果进行比较。在妊娠早期，血浆总皮质醇和游离皮质醇浓度以及尿皮质醇排泄率就已高于产后水平，且在整个孕期持续升高，足月时达到最高水平。妊娠期间糖耐量恶化。当妊娠期间血浆总皮质醇和游离皮质醇浓度以及尿皮质醇排泄率的升高与糖耐量恶化相关联时，得到了显著的正相关（r值在0.55至0.63之间，p小于0.05）。未发现皮质醇水平或排泄率的升高与妊娠期间胰岛素和胰高血糖素对葡萄糖反应的变化之间存在关联。得出的结论是，妊娠期间皮质醇水平的升高可能与妊娠致糖尿病性有关。
