Schwartz S M
Hypertension. 1984 Mar-Apr;6(2 Pt 2):I56-61. doi: 10.1161/01.hyp.6.2_pt_2.i56.
Similar pathologic changes in atherosclerosis and hypertension suggest that some common mechanisms may underlie these two major vascular diseases. Both diseases are characterized by smooth muscle proliferation. The atherosclerotic lesion is characterized by proliferation of smooth muscle cells in the arterial intima of large arteries, leading to vascular occlusion, lipid accumulation, and thrombosis. Smooth muscle proliferation in hypertensive vascular disease again results in increased wall mass and a narrowed lumen. The small vessel change is though to be etiologic of the increased peripheral resistance of high blood pressure. At least in large vessels, the form of proliferation is quite different. Atherosclerosis shows a true cell proliferation. In contrast, smooth muscle cells from animals with hypertensive vascular disease show DNA replication without mitosis. The resulting endoreplication is suggestive of the forms of replication seen in differentiated sarcomeric muscle, particularly in cardiac myocytes.
动脉粥样硬化和高血压中相似的病理变化表明，这两种主要血管疾病可能存在一些共同机制。这两种疾病均以平滑肌增殖为特征。动脉粥样硬化病变的特征是大动脉动脉内膜中平滑肌细胞增殖，导致血管闭塞、脂质蓄积和血栓形成。高血压性血管疾病中的平滑肌增殖再次导致管壁增厚和管腔狭窄。小血管变化被认为是高血压外周阻力增加的病因。至少在大血管中，增殖形式有很大不同。动脉粥样硬化表现为真正的细胞增殖。相比之下，患有高血压性血管疾病的动物的平滑肌细胞显示DNA复制但无有丝分裂。由此产生的核内复制提示了在分化的肌节肌中，特别是心肌细胞中所见的复制形式。
