Miserocchi G, Negrini D, Mortola J P
J Appl Physiol Respir Environ Exerc Physiol. 1984 May;56(5):1151-6. doi: 10.1152/jappl.1984.56.5.1151.
Pleural liquid pressure was measured with saline-filled cannulas in rats, rabbits, cats, pups (4-5 days and 2 mo), small and large dogs, and pigs. On both the costal and mediastinal sides pleural liquid pressure at a level corresponding to the tricuspid valve decreased with increasing body mass; because this behavior was more marked on the mediastinal than on the costal side, a horizontal costomediastinal pleural liquid pressure gradient developed. No differences in liquid pressure were found in animals of different age but of similar size. The protein concentration and the volume-to-body weight ratio of the collected pleural liquid were also found to decrease with increasing body mass. For plasma colloid osmotic pressure, no size-related differences in the Starling balance seem to occur on costal side, whereas such balance shifts toward filtration at mediastinal level with increasing body mass. The lower liquid pressure found with increasing body mass is discussed in terms of lower conductance of the mesothelia and possibly greater lymphatic action. In terms of the Starling-lymphatic interaction we suggest that lymphatics can generate a pressure only slightly lower than that reflecting the equilibrium of the Starling balance of forces.
采用充满生理盐水的插管测量大鼠、家兔、猫、幼犬（4 - 5日龄和2月龄）、小型和大型犬以及猪的胸内液体压力。在与三尖瓣相对应的水平，肋侧和纵隔侧的胸内液体压力均随体重增加而降低；由于这种变化在纵隔侧比肋侧更为明显，因此形成了一个水平的肋纵隔胸内液体压力梯度。在年龄不同但大小相似的动物中未发现液体压力存在差异。还发现所收集的胸内液体的蛋白质浓度和体积与体重之比也随体重增加而降低。对于血浆胶体渗透压，在肋侧似乎未出现与大小相关的Starling平衡差异，而在纵隔水平，随着体重增加，这种平衡向滤过方向转变。随着体重增加而发现的较低液体压力，从间皮细胞较低的传导性以及可能更强的淋巴作用方面进行了讨论。就Starling - 淋巴相互作用而言，我们认为淋巴管产生的压力仅略低于反映Starling力平衡的压力。
