Eady R A, Gunner D B, Tidman M J, Nicolaides K H, Rodeck C H
J Clin Pathol. 1984 Jun;37(6):633-8. doi: 10.1136/jcp.37.6.633.
A method has been developed for rapid processing of fetal skin for prenatal diagnosis of hereditary skin diseases by light and electron microscopy. Fixation, dehydration, embedding, and polymerisation can be achieved in about 5 h. The quality of tissue preservation compares favourably with that produced by slower conventional techniques. This procedure may provoke a wider interest in the potential use of fetal skin biopsy in prenatal diagnosis, especially if identification of structural abnormalities is a feasible alternative to more time consuming biochemical analysis.
已经开发出一种用于快速处理胎儿皮肤的方法，以便通过光学显微镜和电子显微镜对遗传性皮肤病进行产前诊断。固定、脱水、包埋和聚合可在约5小时内完成。组织保存的质量与传统较慢技术所产生的质量相比具有优势。该程序可能会引发人们对胎儿皮肤活检在产前诊断中潜在用途的更广泛兴趣，特别是如果识别结构异常是耗时更长的生化分析的可行替代方法。
