Elkhazen N, Dodion J, Vamos E, Vanregemorter N, Spehl M, Perlmutter N, Rodesch F, Depierreux M, Flament-Durand J
J Gynecol Obstet Biol Reprod (Paris). 1984;13(1):55-66.
Since the very start of using ultrasound to monitor pregnancy the information that the obstetrician has obtained from it has been great. Measuring the fetus (biparietal diameters, rump-crown length etc.) makes it possible to check development of the fetus in the uterus, as well as seeing the various organs and their placing and internal structure. Real time pictures make it possible to visualise the organs precisely from the point of view of their positioning and their internal structures. We report 12 cases of malformations of the central nervous system which were diagnosed in utero and we point out the value of early diagnosis in pregnancy. The 12 cases we found included four of hydrocephaly, one cyst of the choroid plexus, one hydrencephaly , two cases of holoprocencephaly and four cases of anencephaly. Since these malformations may be part of generalised malformations it is important to search for these others by ultrasound as well as by caryotyping and estimation of alpha-fetoprotein levels.
自从开始使用超声监测妊娠以来，产科医生从中获得的信息非常丰富。测量胎儿（双顶径、头臀长度等）能够检查胎儿在子宫内的发育情况，还能观察到各种器官及其位置和内部结构。实时图像使从器官的位置及其内部结构的角度精确可视化这些器官成为可能。我们报告了12例在子宫内诊断出的中枢神经系统畸形病例，并指出了孕期早期诊断的价值。我们发现的12例病例包括4例脑积水、1例脉络丛囊肿、1例积水性无脑畸形、2例全前脑畸形和4例无脑畸形。由于这些畸形可能是全身性畸形的一部分，通过超声以及染色体核型分析和甲胎蛋白水平评估来寻找其他畸形很重要。
