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幻想与现实:解读临床试验中的实际陷阱

Illusion and reality: practical pitfalls in interpreting clinical trials.

作者信息

Glatstein E, Makuch R W

出版信息

J Clin Oncol. 1984 May;2(5):488-97. doi: 10.1200/JCO.1984.2.5.488.

DOI:10.1200/JCO.1984.2.5.488
PMID:6726301
Abstract

This paper has attempted to review for the reader some of the common problem areas in the interpretation of results of cancer treatment. The intention has been to point out potential pitfalls in interpretation so that the reader can comprehend the literature with more insight and criticalness . The plethora of journals and ongoing investigations indicates a greater need for critical understanding on the part of readers. This understanding stretches from the definitions of success and failure used in generating survival curves, to the accumulation and analysis of data and presentation of the results. We hope this paper will help the reader to achieve a greater degree of that understanding.

摘要

本文试图为读者回顾癌症治疗结果解读中一些常见的问题领域。目的是指出解读中潜在的陷阱,以便读者能更有洞察力和批判性地理解相关文献。大量的期刊和正在进行的研究表明读者更需要批判性的理解。这种理解涵盖从生成生存曲线时所使用的成功与失败的定义,到数据的积累、分析以及结果的呈现。我们希望本文能帮助读者在这方面达成更高程度的理解。

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1
Illusion and reality: practical pitfalls in interpreting clinical trials.幻想与现实:解读临床试验中的实际陷阱
J Clin Oncol. 1984 May;2(5):488-97. doi: 10.1200/JCO.1984.2.5.488.
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[From empiricism to therapeutic trials. Or how statistical methods can contribute to the improvement of therapeutic protocols in cervicofacial oncology].[从经验主义到治疗试验。统计学方法如何助力改善头颈部肿瘤的治疗方案]
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Scientific rigour in psycho-oncology trials: why and how to avoid common statistical errors.精神肿瘤学试验中的科学严谨性:为何以及如何避免常见的统计错误。
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Sequential clinical trials in cancer research.癌症研究中的序贯临床试验。
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Barriers to clinical trial recruitment in head and neck cancer.头颈癌临床试验招募的障碍
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Designing for cancer clinical trials: selection of prognostic factors.癌症临床试验设计:预后因素的选择
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Protocol of the Definition for the Assessment of Time-to-event Endpoints in CANcer trials (DATECAN) project: formal consensus method for the development of guidelines for standardised time-to-event endpoints' definitions in cancer clinical trials.癌症临床试验中评估时间事件终点的定义方案(DATECAN)项目:为癌症临床试验中标准化时间事件终点定义制定指南的正式共识方法。
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Multivariate analysis of clinical prognostic factors in patients with glioblastoma multiforme treated with a combined modality approach.多形性胶质母细胞瘤患者采用综合治疗方法的临床预后因素多变量分析。
J Cancer Res Clin Oncol. 2003 Aug;129(8):477-84. doi: 10.1007/s00432-003-0471-5. Epub 2003 Jul 15.
2
Pretreatment clinical prognostic factors in patients with stage IV non-small cell lung cancer (NSCLC) treated with chemotherapy.接受化疗的IV期非小细胞肺癌(NSCLC)患者的预处理临床预后因素。
J Cancer Res Clin Oncol. 2003 Feb;129(2):114-22. doi: 10.1007/s00432-002-0408-4. Epub 2003 Mar 7.
3
Prognostic factors in non-small cell lung cancer: multiregression analysis in the National Cancer Center Hospital (Japan).
非小细胞肺癌的预后因素:日本国立癌症中心医院的多元回归分析
J Cancer Res Clin Oncol. 1987;113(6):563-6. doi: 10.1007/BF00390866.