Oldendorf W H
J Nucl Med. 1984 Feb;25(2):253-69.
A technique is described in which the mean circulation (transit) time of each hemisphere is determined by means of an intravenous radioisotope technique. A sharp bolus of a rapidly excreted I131 labeled compound is released from an antecubital vein. The time of entrance into the brain blood pool of the densest portion of this bolus is determined by plotting the first derivative of the amount of isotope seen in the brain by a paired external collimation-detection system. The time of exit of the densest portion of the bolus is also similarly determined. The interval between the entrance and exit represents, we believe, the mean cerebral transit time. In 15 normal males transit times were obtained between 6.5 and 10 seconds. The test is virtually painless, repeatable, and exposes the patient to minimal radiation.
本文描述了一种技术，通过静脉注射放射性同位素技术来测定每个半球的平均循环（通过）时间。从肘前静脉快速注入一针团快速排泄的碘-131标记化合物。通过配对的外部准直检测系统绘制大脑中所见同位素量的一阶导数，来确定该针团最密集部分进入脑血池的时间。针团最密集部分的流出时间也以类似方式确定。我们认为，进入和流出之间的间隔代表平均脑通过时间。在15名正常男性中，通过时间在6.5至10秒之间。该测试几乎无痛、可重复，且使患者受到的辐射最小。
