将顺磁性物质硫化锰胶体用作大鼠的核磁共振造影剂。

Use of a paramagnetic substance, colloidal manganese sulfide, as an NMR contrast material in rats.

作者信息

Chilton H M, Jackels S C, Hinson W H, Ekstrand K E

出版信息

J Nucl Med. 1984 May;25(5):604-7.

Abstract

Paramagnetic pharmaceuticals ( magnetopharmaceuticals ) that are suitably distributed into specific organ systems or diseased sites might be clinically useful for tissue contrast enhancement in nuclear magnetic resonance images. To determine whether an insoluble magnetopharmaceutical might be useful in such service, we investigated the effect of a colloidal preparation of manganese sulfide ( MnSC ) upon liver and lung spin-lattice relaxation times (T1) in rats following intravenous administration. NMR tissue sample measurements were made at 24 MHz, ahd showed that after MnSC treatment, liver T1 values--and to a lesser extent lung T1 values--were depressed below control values. Liver manganese content (as determined by flame atomic absorption spectrophotometry) increased in proportion to the dose of MnSC , and the reciprocal of the liver T1 values also increased in proportion to the dose of MnSC .

摘要

能适当地分布于特定器官系统或患病部位的顺磁性药物（磁药物）在临床上可能有助于增强核磁共振图像中的组织对比度。为了确定一种不溶性磁药物是否适用于此用途，我们研究了硫化锰胶体制剂（MnSC）静脉注射后对大鼠肝脏和肺自旋晶格弛豫时间（T1）的影响。在24兆赫下对核磁共振组织样本进行测量，结果显示，经MnSC处理后，肝脏T1值——以及程度稍轻的肺T1值——低于对照值。肝脏锰含量（通过火焰原子吸收分光光度法测定）与MnSC剂量成正比增加，肝脏T1值的倒数也与MnSC剂量成正比增加。