Ha C, Kerkvliet N I, Miller L T
J Nutr. 1984 May;114(5):938-48. doi: 10.1093/jn/114.5.938.
The effect of vitamin B-6 deficiency on in vivo host susceptibility to primary Moloney sarcoma virus (MSV)-induced tumor growth and to secondary challenge with MSB sarcoma cells was examined in mice. Female C57BL/6 mice, 6 weeks of age, were fed 20% casein diets with pyridoxine (PN) added at 1, 0.5, 0.1 or 0 mg/kg diet for 21 weeks. After 4 weeks of dietary treatment the mice were challenged with MSV. Vitamin B-6 deficiency resulted in an enhancement of tumor susceptibility as well as an increase in tumor size and regression time. The animals resistant to both MSV and MSV-transformed tumor cells ( MSB ) challenge showed splenic tumor development at necropsy 51 days after MSB challenge. Total incidence of MSV/ MSB /splenic tumors was 2/11, 2/11, 4/10 and 8/11 in animals fed PN 1, 0.5, 0.1 and 0 diets, respectively. Since MSV-induced tumors regressed spontaneously in immunocompetent hosts, the increased susceptibility to MSV oncogenesis in vitamin B-6-deficient animals suggests that reactivity of T cells and/or other effector cells is impaired in vitamin B-6-deficient animals suggests that reactivity of T cells and/or other effector cells is impaired in vitamin B-6 adequacy.
在小鼠中研究了维生素B-6缺乏对体内宿主对原发性莫洛尼肉瘤病毒（MSV）诱导的肿瘤生长以及对MSB肉瘤细胞二次攻击的易感性的影响。6周龄的雌性C57BL/6小鼠被喂食添加了1、0.5、0.1或0mg/kg饮食的吡哆醇（PN）的20%酪蛋白饮食，持续21周。饮食处理4周后，小鼠接受MSV攻击。维生素B-6缺乏导致肿瘤易感性增强以及肿瘤大小和消退时间增加。对MSV和MSV转化的肿瘤细胞（MSB）攻击均有抗性的动物在接受MSB攻击后51天尸检时出现脾脏肿瘤。分别喂食PN 1、0.5、0.1和0饮食的动物中，MSV/MSB/脾脏肿瘤的总发生率分别为2/11、2/11、4/10和8/11。由于MSV诱导的肿瘤在免疫活性宿主中会自发消退，维生素B-6缺乏动物对MSV致癌作用易感性增加表明，维生素B-6缺乏动物中T细胞和/或其他效应细胞的反应性受损，提示维生素B-6充足时T细胞和/或其他效应细胞的反应性受损。
