Biological functions of hydroxylamine inactivated influenza virus.

Hydroxylamine inactivates members of the orthomyxovirus group. Studies with inactivated influenza virus indicate that the genome of such virus does not serve for the production of functional viral proteins. Additional evidence indicated that the genome may, however, undergo limited replication. These observations are correlated with the inactivation of influenza virus and the known mechanism of action of hydroxylamine.