Wang J M, Gu C H, Qian Z M, Jing G W
J Reprod Fertil. 1984 May;71(1):127-33. doi: 10.1530/jrf.0.0710127.
Rats were treated with highly purified gossypol acetic acid at doses of 15 or 30 mg/kg day-1 for 6 weeks to produce an effect on spermatogenesis as shown by reduced sperm motility and increased sperm malformation rates. The treated rats did not differ from the controls in the body weight growth curves and reproductive organ weights. When stimulated with hCG, testicular blood flow was increased in the low dose group; the testosterone concentrations in peripheral and testicular venous blood were also increased to a greater extent than those of the control group. No difference was found between the high dose and control groups in testicular blood flow or testosterone concentrations. The morphology of the Leydig cells was apparently normal, although some degenerative changes in the germinal epithelium were observed in the high dose group. Therefore, there is no evidence in our experiment to show any anti-androgenic effect following 6-week treatment of gossypol in rats, even at the dose of 30 mg/kg day-1.
给大鼠每日按15或30mg/kg的剂量给予高度纯化的醋酸棉酚，持续6周，以对精子发生产生影响，表现为精子活力降低和精子畸形率增加。处理后的大鼠在体重增长曲线和生殖器官重量方面与对照组没有差异。用hCG刺激时，低剂量组的睾丸血流量增加；外周和睾丸静脉血中的睾酮浓度也比对照组有更大程度的升高。高剂量组与对照组在睾丸血流量或睾酮浓度方面没有差异。尽管在高剂量组观察到生精上皮有一些退行性变化，但睾丸间质细胞的形态明显正常。因此，在我们的实验中，没有证据表明大鼠经6周棉酚处理后会产生任何抗雄激素作用，即使是在每日30mg/kg的剂量下。
