Ogihara M, Tokumitsu Y, Ui M
Jpn J Pharmacol. 1984 Mar;34(3):307-11. doi: 10.1254/jjp.34.307.
We studied the influence of prolonged starvation on carbohydrate metabolism in streptozotocin-diabetic rats compared with normal rats. In streptozotocin (STZ)-diabetic rats, the plasma glucose concentration decreased gradually during prolonged starvation, while it did not change in normal rats. In normal rats, glycogen depletion in the liver occurred within 24 hr of starvation, while in STZ-diabetic rats, glycogen content did not change even after 72 hr of starvation. Impaired glucose tolerance and glycogen deposition in response to oral administration of glucose were observed in STZ-diabetic rats compared with normal animals. STZ-diabetic animals generally had lower glycogen synthase and phosphorylase activities compared with normal rats during starvation. In normal animals, there is a significant correlation between the plasma concentration of free fatty acids and 3-hydroxybutyrate. On the basis of these findings, metabolic alterations in chemically-induced diabetic animals were discussed.
我们研究了与正常大鼠相比，长期饥饿对链脲佐菌素诱导的糖尿病大鼠碳水化合物代谢的影响。在链脲佐菌素（STZ）诱导的糖尿病大鼠中，长期饥饿期间血浆葡萄糖浓度逐渐降低，而正常大鼠的血浆葡萄糖浓度没有变化。在正常大鼠中，饥饿24小时内肝脏糖原耗尽，而在STZ诱导的糖尿病大鼠中，即使饥饿72小时后糖原含量也没有变化。与正常动物相比，STZ诱导的糖尿病大鼠口服葡萄糖后出现葡萄糖耐量受损和糖原沉积。在饥饿期间，与正常大鼠相比，STZ诱导的糖尿病动物的糖原合酶和磷酸化酶活性通常较低。在正常动物中，游离脂肪酸和3-羟基丁酸的血浆浓度之间存在显著相关性。基于这些发现，讨论了化学诱导的糖尿病动物的代谢改变。
