Christiansen C, Christensen M S, Grande P, Transbøl I
Maturitas. 1984 Mar;5(3):193-9. doi: 10.1016/0378-5122(84)90052-5.
Female hormones are known in influence serum lipoproteins. In post-menopausal women oestrogens decrease the concentration of low-density lipoprotein (LDL) and increase that of high-density lipoprotein (HDL), while progestogens may have the opposite effect. The risk of coronary heart disease (CHD) should consequently be decreased by oestrogens and increased by progestogens. We report here the changes observed in serum total cholesterol, triglycerides, and lipoproteins in post-menopausal women during sequential oestrogen/progestogen treatment. Oestriol and 17 beta-oestradiol were given alone for the first 12 days, in combination with norethisterone acetate (1 mg/day) for the next 10 days, and then in reduced amounts for the last 6 days of the 28-day cycle. Three different doses of the oestrogens were investigated (high, medium and low). A total of 177 normal post-menopausal women volunteered for random allocation to treatment or placebo groups. Blood samples were taken every 3 mth during the progestogen phase of the cycle. Serum total cholesterol was found to be 10-13% lower over a 3-yr period on the high oestrogen dose and 5 and 3% lower on the medium and low doses, respectively. No significant changes were seen in serum triglycerides. Determination of lipoprotein fractions showed that the reduction in total cholesterol was due to reduced LDL-cholesterol, the HDL-cholesterol levels remaining virtually unchanged.
已知女性激素会影响血清脂蛋白。在绝经后女性中，雌激素会降低低密度脂蛋白（LDL）的浓度，升高高密度脂蛋白（HDL）的浓度，而孕激素可能会产生相反的效果。因此，雌激素应会降低冠心病（CHD）的风险，而孕激素则会增加其风险。我们在此报告绝经后女性在序贯雌激素/孕激素治疗期间血清总胆固醇、甘油三酯和脂蛋白的变化情况。雌三醇和17β-雌二醇在前12天单独给药，接下来10天与醋酸炔诺酮（1毫克/天）联合给药，然后在28天周期的最后6天减少剂量。研究了三种不同剂量的雌激素（高、中、低）。共有177名正常绝经后女性自愿随机分配到治疗组或安慰剂组。在周期的孕激素阶段，每3个月采集一次血样。发现在3年期间，高剂量雌激素组的血清总胆固醇降低了10 - 13%，中剂量和低剂量组分别降低了5%和3%。血清甘油三酯未见明显变化。脂蛋白组分的测定表明，总胆固醇的降低是由于低密度脂蛋白胆固醇降低，高密度脂蛋白胆固醇水平基本保持不变。
