Tams T R
Mod Vet Pract. 1984 Feb;65(2):107-14.
Ampicillin or amoxicillin is a good initial choice for treatment of liver disease involving bacteria. Cephalosporins, among other antibiotics, can be used with aminoglycosides for a broad-spectrum effect. Metronidazole may benefit patients with hepatic encephalopathy. Tetracycline, penicillins and cephalosporins are good choices for biliary disease. Corticosteroids are indicated for chronic active hepatitis, cholangiohepatitis, immune-mediated hepatopathy, and hepatic lymphosarcoma and mast-cell tumors. D-penicillamine is used to treat hepatic Cu toxicosis. Colchicine has been used to combat hepatic fibrosis. Lactulose is used in long-term management of hepatic encephalopathy. Diuretics and a low-Na diet help control ascites. Cimetidine is used to control GI ulcers. Anabolic steroids help reverse protein catabolism. Acetylcysteine is an antidote for acetaminophen toxicity. Use of hetacillin, chloramphenicol, lincomycin, sulfonamides, erythromycin, acetaminophen and methyltestosterone should be avoided in patients with liver disease.
氨苄西林或阿莫西林是治疗涉及细菌的肝病的良好初始选择。除其他抗生素外，头孢菌素可与氨基糖苷类药物联合使用以产生广谱效应。甲硝唑可能对肝性脑病患者有益。四环素、青霉素和头孢菌素是胆道疾病的良好选择。皮质类固醇适用于慢性活动性肝炎、胆管肝炎、免疫介导的肝病以及肝淋巴肉瘤和肥大细胞瘤。D-青霉胺用于治疗肝铜中毒。秋水仙碱已被用于对抗肝纤维化。乳果糖用于肝性脑病的长期管理。利尿剂和低钠饮食有助于控制腹水。西咪替丁用于控制胃肠道溃疡。合成代谢类固醇有助于逆转蛋白质分解代谢。乙酰半胱氨酸是对乙酰氨基酚中毒的解毒剂。肝病患者应避免使用海他西林、氯霉素、林可霉素、磺胺类药物、红霉素、对乙酰氨基酚和甲基睾酮。
