Puzyńska L
Nahrung. 1984;28(2):173-83. doi: 10.1002/food.19840280219.
Male and female rats of Wistar strain were fed from the 6th week of life on during 10 and 30 days the diet containing 4.5% or 26% protein without or with addition of chlorfenvinphos (Chl) in concentrations of 5, 100 and 1000 ppm. The following was stated: In the case of optimal-protein diet (26% protein): the inhibitory effect of Chl on the body weight gain at its highest concentration; the increased relative weight of liver, ovaries and adrenals dependent on the amount of the insecticide in the diet. In the case of low-protein diet (4.5% protein): the reduced rate of the body weight gain already at 5 ppm, pronounced at 100 ppm and strongly marked at 1000 ppm of Chl; increase of the relative weight of testicles, adrenals and decrease of the relative weight of the spleen connected with the increasing concentrations of Chl. In rats with the most decreased rate of the body weight gain (in case of Chl) an increase of the relative weight of the brain. Congestion of the heart, spleen and kidneys after 30 days on diets containing 100 and 1000 ppm of Chl, independent of the amount of protein in the diet. Eosinophilic infiltrations in the lungs of rats obtaining the 100 ppm-contaminated low-protein diet during 30 days. Focal degenerative changes in the cells of the exocrine pancreas and proliferation of lymphatic nodules in the spleen mainly in rats receiving the 1000 ppm-contaminated optimal-protein diet for 30 days. After withdrawal of Chl from the diets changes caused by this insecticide showed reversal trends.
从出生后第6周开始，给Wistar品系的雄性和雌性大鼠喂食含4.5%或26%蛋白质的饲料，持续10天和30天，饲料中添加或不添加浓度为5、100和1000 ppm的毒虫畏（Chl）。结果表明：在蛋白质含量最佳的饲料（26%蛋白质）情况下，Chl在最高浓度时对体重增加有抑制作用；肝脏、卵巢和肾上腺的相对重量增加，这取决于饲料中毒虫畏的含量。在蛋白质含量低的饲料（4.5%蛋白质）情况下，Chl在5 ppm时体重增加率就已降低，在100 ppm时明显降低，在1000 ppm时显著降低；睾丸、肾上腺的相对重量增加，脾脏的相对重量减少，且与Chl浓度增加有关。在体重增加率下降最明显的大鼠（Chl处理组）中，大脑的相对重量增加。在含100和1000 ppm Chl的饲料喂养30天后，心脏、脾脏和肾脏出现充血，这与饲料中蛋白质含量无关。在30天内摄入含100 ppm Chl的低蛋白污染饲料的大鼠肺部出现嗜酸性粒细胞浸润。外分泌胰腺细胞出现局灶性退行性变化，脾脏淋巴小结增生，主要发生在接受1000 ppm Chl污染的最佳蛋白质饲料喂养30天的大鼠中。从饲料中撤掉Chl后，这种杀虫剂引起的变化呈现出逆转趋势。
