Russegger L, Kostron H, Twerdy K, Grunert V
Neurochirurgia (Stuttg). 1984 Mar;27(2):39-43. doi: 10.1055/s-2008-1053723.
In 27 patients, who suffered from SAH from a ruptured cerebral aneurysm direct operation and treatment with Nimodipine (Bay e 9736) was performed. Nimodipine was given intravenously over ten days (30 micrograms/kg bodyweight/hour) and thereafter orally over four days in diminishing dosages. There were no noteworth side effects. In comparison with a group of nine similar patients who were not given Nimodipine the study shows that Nimodipine is not able to reduce angiographic spasm or brain oedema in CT-scan. In spite of that the general recovery with Nimodipine was better than in the control group. The worse the initial neurological symptoms are, the more effective Nimodipine seems to be. The study shows that treatment should begin between the first and sixth day after SAH, at least two days before operation and at the latest two days after the onset of secondary spasm.
对27例因脑动脉瘤破裂导致蛛网膜下腔出血（SAH）的患者进行了直接手术，并使用尼莫地平（拜耳e 9736）进行治疗。尼莫地平静脉给药10天（30微克/千克体重/小时），之后口服4天，剂量逐渐减少。未观察到明显的副作用。与一组9例未使用尼莫地平的类似患者相比，该研究表明尼莫地平不能减轻血管造影显示的痉挛或CT扫描中的脑水肿。尽管如此，使用尼莫地平后的总体恢复情况优于对照组。初始神经症状越严重，尼莫地平似乎越有效。该研究表明，治疗应在SAH后的第1天至第6天开始，至少在手术前2天，最迟在继发性痉挛发作后2天。
