Wilson M G, Marchese C A
Prenat Diagn. 1984 Jan-Feb;4(1):61-6. doi: 10.1002/pd.1970040109.
An apparently normal female infant was born after the prenatal diagnosis of fragile Xq27-28 present in about 4 per cent of amniocytes . The mildly retarded mother had been found in early pregnancy to be heterozygous for fragile X. The child, now 9 months old, showed about the same level of fragile X expression as her mother. Variations in the proportion of cells with fragile X appeared to be related to cell type and laboratory techniques. The infant's growth and development have been normal. Different techniques to induce or increase the expression of fragile X are discussed.
一名外表正常的女婴在产前诊断出约4%的羊水细胞存在脆性Xq27 - 28后出生。这位轻度智力发育迟缓的母亲在怀孕早期被发现为脆性X基因杂合子。这个孩子现在9个月大，其脆性X表达水平与她母亲大致相同。含有脆性X的细胞比例变化似乎与细胞类型和实验室技术有关。该婴儿的生长发育一直正常。文中讨论了诱导或增加脆性X表达的不同技术。
