Rech R H, Borsini F, Samanin R
Pharmacol Biochem Behav. 1984 Apr;20(4):489-93. doi: 10.1016/0091-3057(84)90293-4.
d-Amphetamine and d-fenfluramine caused different patterns of disruption in a learned maze performance reinforced with food. A 0.8 mg/kg dose of amphetamine increased correct and incorrect (errors) alley entrances as well as earned reinforcers consumed. Larger doses (1.6-3.2 mg/kg) decreased correct responses, increased errors, and resulted in earned reinforcers not being consumed. Metergoline pretreatment did not reverse these deficits. d-Fenfluramine (1.5 and 3.0 mg/kg) reduced correct responses dose- relatedly with a slight increase in errors after the larger dose; all earned reinforcers were consumed. Pretreatment with metergoline reversed the deficit in correct responses but not the errors. Combinations of d-amphetamine and d-fenfluramine produced greater deficits than each drug separately, with fewer correct responses and an increase in reinforcers earned but not consumed. Metergoline pretreatment before the combination did not reverse these effects but increased alley entrances scored as errors. The results indicate that the d-fenfluramine but not the d-amphetamine deficit relates to a 5-hydroxytryptamine (5-HT) mechanism. Furthermore, the enhanced effect of the combination appears to relate to drug interactions not dependent upon a 5-HT component.
右旋苯丙胺和右旋芬氟拉明在以食物强化的习得性迷宫任务中导致了不同的破坏模式。0.8毫克/千克剂量的苯丙胺增加了正确和错误（失误）的通道进入次数以及获得的强化物消耗量。更大剂量（1.6 - 3.2毫克/千克）减少了正确反应，增加了失误，并导致获得的强化物未被消耗。麦角新碱预处理并未逆转这些缺陷。右旋芬氟拉明（1.5和3.0毫克/千克）与剂量相关地减少了正确反应，较大剂量后失误略有增加；所有获得的强化物都被消耗了。麦角新碱预处理逆转了正确反应的缺陷，但未逆转失误。右旋苯丙胺和右旋芬氟拉明的组合产生的缺陷比每种药物单独使用时更大，正确反应更少，获得但未消耗的强化物增加。组合用药前的麦角新碱预处理并未逆转这些效应，但增加了被计为失误的通道进入次数。结果表明，右旋芬氟拉明而非右旋苯丙胺的缺陷与5-羟色胺（5-HT）机制有关。此外，组合用药的增强效应似乎与不依赖5-HT成分的药物相互作用有关。
