Berenson M M, Cardinal J R
Res Commun Chem Pathol Pharmacol. 1984 Apr;44(1):113-22.
The effects of incorporation of chlorpromazine, pentobarbital and ethinyl estradiol on the maintenance of cholesterol supersaturation was studied in bile analogs. Bile solutions were initially supersaturated and microscopically clear. Chlorpromazine and pentobarbital were almost totally solubilized; ethinyl estradiol was poorly solubilized. Chlorpromazine and pentobarbital in concentrations of 5 and 10 mg/ml rapidly (less than 3-5 h) diminished cholesterol in bile filtrates compared to controls; ethinyl estradiol did so at a concentration of 1 mg/ml but less rapidly (24 h). Bile acid and lecithin concentrations, over time, did not differ significantly between groups. The results indicate that drug interactions with bile constituents, without causing their precipitation, can alter the maintenance of cholesterol supersaturation and phase transitions in bile.
在胆汁类似物中研究了氯丙嗪、戊巴比妥和炔雌醇掺入对胆固醇过饱和维持的影响。胆汁溶液最初是过饱和且显微镜下澄清的。氯丙嗪和戊巴比妥几乎完全溶解；炔雌醇溶解性较差。与对照组相比，浓度为5和10mg/ml的氯丙嗪和戊巴比妥能迅速（少于3 - 5小时）降低胆汁滤液中的胆固醇；炔雌醇在浓度为1mg/ml时也能降低胆固醇，但速度较慢（24小时）。随着时间推移，各组之间胆汁酸和卵磷脂浓度无显著差异。结果表明，药物与胆汁成分的相互作用，在不引起其沉淀的情况下，可改变胆汁中胆固醇过饱和的维持和相变。
