Chan I M, Tolentino F I, Refojo M F, Fournier G, Albert D M
Retina. 1984 Winter-Spring;4(1):51-9.
We studied a synthetic hydrogel, PHEA [poly(2-hydroxyethyl acrylate)], experimentally. The material is transparent, autoclavable , highly viscous, nonabsorbable, easily injectable, cohesive, and does not fragment on passage through small-gauge needles. Results in animal studies revealed that injection of PHEA into the vitreous cavity promoted inflammatory changes such as vitreous haziness , membrane formation, and chorioretinal atrophy. Histopathologic studies showed extensive retinal disorganization, chorioretinal scarring, and vitritis . We reviewed the literature and concluded that an ideal vitreous substitute for long-term use in complex cases of retinal detachment is not available at this time.
我们对一种合成水凝胶聚（2 - 羟乙基丙烯酸酯）（PHEA）进行了实验研究。该材料透明、可高压灭菌、高粘性、不可吸收、易于注射、有粘性，且通过小口径针头时不会破碎。动物研究结果显示，向玻璃体腔注射PHEA会引发炎症变化，如玻璃体混浊、膜形成和脉络膜视网膜萎缩。组织病理学研究表明存在广泛的视网膜结构紊乱、脉络膜视网膜瘢痕形成和葡萄膜炎。我们查阅了文献并得出结论，目前尚无一种理想的玻璃体替代物可用于视网膜脱离复杂病例的长期治疗。
