Soulier J P, Gozin D, Lerable J
Thromb Res. 1984 May 1;34(3):255-62. doi: 10.1016/0049-3848(84)90009-4.
15 rabbits and 6 dogs were injected with a mixture of thrombin and heparin. Increasing amounts of thrombin, and various ratio of thrombin in relation to heparin, were used. It was found that huge amounts of thrombin could be perfused, under the protection of heparin, without untoward effects. But the high amount of thrombin needed to obtain a 50% reduction of the circulating AT III required a corresponding high amount of protective heparin. Since the secondary injection of protamin sulphate (after the end of the perfusion with the thrombin-heparin mixture) was precipitating the DIC syndrome, such attempts to decrease AT III in man are not feasible.
给15只兔子和6只狗注射了凝血酶和肝素的混合物。使用了不断增加剂量的凝血酶以及凝血酶与肝素的各种比例。结果发现，在肝素的保护下，可以灌注大量凝血酶而无不良影响。但是，要使循环中的抗凝血酶III减少50%所需的高剂量凝血酶需要相应高剂量的保护性肝素。由于在（用凝血酶-肝素混合物灌注结束后）二次注射硫酸鱼精蛋白会引发弥漫性血管内凝血综合征，因此在人体中降低抗凝血酶III的此类尝试不可行。
